Those of you trying to override the FSAA settings ingame, have you disabled HDR? Depending on ther engine, HDR/Bloom can render FSAA unseable (I.e., it just won't work). That may be why they used Multisampling as a method in-game (since it works with this engine with HDR on or off). I'm guessing your videocards can't override the FSAA in-game because most people probably have the HDR on by default. Trying turning off HDR in-game and then setting your FSAA options via your driver's CP. Not sure if this will work, but it's worth a shot.